Metabolic Syndrome & Diabetes
Reduction of elevated lipids and low‐density lipoprotein oxidation
in serum of individuals with subclinical hypoxia and oxidative stress supplemented with lycosome formulation of docosahexaenoic acid. - Ivan M. Petyaev, Pavel Y. Dovgalevsky, Natalia E. Chalyk, Victor A. Klochkov, Nigel H. Kyle (2019) Food Sci Nutr., Volume 7, Issue 2–9, DOI: 10.1002/fsn3.784
Reduction of Liver Span and Parameters of Inflammation in Nonalcoholic Fatty Liver Disease Patients
Treated with Lycosome Formulation of Phosphatidylcholine: A Preliminary Report - Ivan M. Petyaev, Pavel Y. Dovgalevsky, Natalia E. Chalyk, Victor A. Klochkov, Nigel H. Kyle, and Yuriy K. Bashmakov (2018) Hindawi
International Journal of Chronic Diseases Volume, Article ID 4549614, 7
Old Drug Acquires New Target:
Old Drug Acquires New Target: Metformin and Sirt 1. – Yuriy K Bashmakov and Ivan M Petyaev (2011) J. Diabetes Metab., 2003, v 2, 8, Editorial.
Metabolic Mechanisms of Failure of Intraportally
Metabolic Mechanisms of Failure of Intraportally Transplanted Pancreatic betta-cells in Rats. – Young L., Ravazzola M., Park BH, Bashmakov YK. Orci L., Unger R. (2007) Diabetes, 56:2295-2301.
Overexpression of Sterol Regulatory Element-Binding Protein
Overexpression of Sterol Regulatory Element-Binding Protein -Ia in Mouse Adipose Tissue Produces Adipocytes Hypertrophy, increased Fatty Acid Secretion, and Fatty liver. – Horton, J.D., Shimomura, I., Ikemoto. S., Bashmakov, Y., Hammer, R.E. (2003) J. Biol. Chem., 2003, 278:36652-36660.
Insulin inhibits transcription of IRS-2 gene in rat liver
Insulin inhibits transcription of IRS-2 gene in rat liver through an insulin response element (IRE) that resembles IREs of other insulin-repressed genes. – Zhang, J., Ou, J., Bashmakov, Y., Horton, J.D., Brown, M.S., and Goldstein, M.S. (2001) Proceedings of National Academy of Sciences, USA PNAS, 98:3756-3761.
Decreased IRS-2 and increased SREBP-1c lead to mixed insulin
Decreased IRS-2 and increased SREBP-1c lead to mixed insulin resistance and sensitivity in livers of lipodystrophic and ob/ob mice. – Shimomura, I., Matsuda, M., Hammer, R.E., Bashmakov, Y., Brown, M.S., and Goldstein, J.L. (2000) Molecular Cell, 6:77-86.
Insulin selectively increases SREBP-1c mRNA
Insulin selectively increases SREBP-1c mRNA in the livers of rats with streptozotocin-induced diabetes. – Shimomura, I., Bashmakov, Y., Ikemoto, S., Horton, J.D., Brown, M.S., and Goldstein, J.L. (1999) Proceedings of National Academy of Sciences, USA PNAS, 96:13656-13661.
Increased levels of nuclear SREBP-1c
Increased levels of nuclear SREBP-1c associated with fatty livers in two mouse models of diabetes mellitus. – Shimomura, I., Bashmakov, Y., and Horton, J.D. (1999) J. Biol. Chem., 274:30028-30032.
Insulin resistance and diabetes mellitus in transgenic mice
Insulin resistance and diabetes mellitus in transgenic mice expressing nuclear SREBP-1c in adipose tissue: model for congenital generalized lipodystrophy. – Shimomura, I., Hammer, R.E., Richardson, J.A., Ikemoto S., Bashmakov, Y., Goldstein, J.L., and Brown, M.S. (1998) Genes Dev., 12:3182-3194.
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