Lipid Metabolism
Improvement of hepatic bioavailability
Improvement of hepatic bioavailability as a new step for the future of statin – Ivan M Petyaev, Arch Med Sci. 2015 Apr 25; 11(2): 406–410.
World Biomedical Frontiers (2015)
ISSN: 2328-016
Unsaturated fatty acids inhibit transcription of the sterol regulatory
Unsaturated fatty acids inhibit transcription of the sterol regulatory element-binding protein -1c (SREBP-1c) gene by antagonizing ligand-dependent activation of the LXR. – Ou, J., Tu, H., Shan, B., Luk, A., DeBose-Boyd, R., Bashmakov, Y., Goldstein, J.L., and Brown, M.S. (2001) Proceedings of National Academy of Sciences, USA PNAS, 2, 98: 6027-6032.
Regulation of mouse sterol regulatory element-binding protein-1c gene
Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXR alpha and LXR beta. – Repa, J.J., Liang, G., Ou, J., Bashmakov, Y., Lobaccaro, J.-M.A., Shimomura, I., Shan, B., Brown, M.S., Goldstein, J.L., and Mangelsdorf, D.J. (2000) Genes Dev., 14:2819-2830.
Blunted feedback suppression of SREBP processing by dietary cholesterol
Blunted feedback suppression of SREBP processing by dietary cholesterol in transgenic mice expressing sterol-resistant SCAP (D443N). – Korn, B.S., Shimomura, I., Bashmakov, Y., Hammer, R.E., Horton, J.D., Goldstein, J.L., and Brown, M.S. (1998) J. Clin. Invest., 1998, 102:2050-2060.
Nuclear sterol regulatory element-binding proteins activate genes
Nuclear sterol regulatory element-binding proteins activate genes responsible for the entire program of unsaturated fatty acid biosynthesis in transgenic mouse liver. – Shimomura, I., Shimano, H., Korn, B.S., Bashmakov, Y., Horton, J.D (1998), J. Biol. Chem., 273:35299-35306.
Regulation of sterol regulatory element-binding proteins
Regulation of sterol regulatory element-binding proteins in livers of fasted and refed mice. – Horton, J.D., Bashmakov, Y., Shimomura, I., and Shimano, H. (1998) Proceedings of National Academy of Sciences, PNAS USA, 95:5987-5992.
Cholesterol feeding reduces nuclear forms of sterol regulatory element-binding proteins
Cholesterol feeding reduces nuclear forms of sterol regulatory element-binding proteins in hamster liver. – Shimomura, I., Bashmakov, Y., Shimano, H., Horton, J.D., Goldstein, J.L., and Brown, M.S. (1997) Proceedings of National Academy of Sciences, PNAS USA , 94:12354-12359.
Statins Induce Plasma Levels of Proprotein Convertase Subtilisin/Kexin
Statins Induce Plasma Levels of Proprotein Convertase Subtilisin/Kexin Type 9. – Lagace TA, Bashmakov Y., Anderson N.N, McNutt MC, Grefhorst A, HO YK, Horton JD. (2008) FASEB Journal, 22, 1040.
Decreased Plasma Cholesterol and Hypersensitivity to Statins in Mice Lacking
Decreased Plasma Cholesterol and Hypersensitivity to Statins in Mice Lacking Pcsk9. Shirya Rashid, David E.Curtis, Rita Garuti, Norma N.Anderson, Yuriy Bashmakov, Y.K.Ho, Robert Hammer, Young-Ah Moon, Jay D. Horton. (2005) Proceedings of National Academy of Sciences, USA PNAS, 102:5374-5379.
Characterization of Mouse Short-chain Aldehyde Reductase (SCALD)
Characterization of Mouse Short-chain Aldehyde Reductase (SCALD), an Enzyme Regulated be Sterol Regulatory Element-binding Proteins. – Kasus-Jacobi, A., Ou, O. , Bashmakov, Y., Shelton, J. M., Richardson J. A., Goldstein J.L.,Brown, M.S. (2003) J. Biol. Chem., 278: 32380-32389.
Upregulation of Hepatic LDL Transport by n-3 Fatty Acids in LDL Receptor Knockout Mice.
Upregulation of Hepatic LDL Transport by n-3 Fatty Acids in LDL Receptor Knockout Mice. – Vasandani, C., Kafrouni, A.I., Caronna, A., Bashmakov, Y., Gotthardt, M., Horton, J.D., and Spady, D.K.: (2002) J. Lipid Res., May, 43(5):772-84
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